High-frequency (HF) EP DBS produces frequency band-specific and time-dependent increases and decreases in LFP oscillation power in primary motor cortex (M1), striatum (STR) and ventroanterior thalamus (VA).

<p><b>A.</b> Color plots showing effects of high-frequency (HF; top) or SHAM (bottom) EP DBS on normalized LFP power in M1, STR, and VA according to frequency band and time point. * = significantly different from SHAM; # significantly different from within-group BL (p<0.05). * = significantly different from SHAM; # significantly different from within-group BL (p<0.05). <b>B.</b> Representative power spectra from a rat receiving HF EP DBS at BL, in the first five minutes of stimulation (On5), and after 90 minutes of stimulation (Off90). Shaded area represents 95% confidence interval generated using “leave one out” jackknife statistics. <b>C.</b> Effects of HF and SHAM EP DBS on normalized M1 low beta (top) and high gamma (bottom) power over time. Error bars represent S.E.M. <b>D.</b> Effects of EP DBS on M1 low beta power, pooled according to relative stimulation time point. OFF = pooled average of BL, Off30, Off60; “ON+5” = pooled average of On5, On35, On 65; “ON+25” = average of On25, On55, On85. * = significantly different from SHAM; # = significantly different from within-group BL (p<0.05).