<i>lin-42</i> suppresses neuronal phenotypes associated with <i>lsy-6</i> miRNA-mediated cell fate specification.

<p>(A) A diagram of a <i>C. elegans</i> larva illustrating the location of the gustatory neurons, ASEL and ASER, whose asymmetric patterns of gene expression are controlled by the ASEL-specific expression of the <i>lsy-6</i> miRNA. Mutations in <i>lsy-6</i> result in animals that fail to express the ASEL-specific cell fate reporter <i>Plim-6::GFP</i>. (B) Quantification of <i>Plim-6::GFP</i> expression phenotypes of <i>lsy-6</i>, <i>lin-42</i>, <i>alg-1</i>, and <i>lin-42; alg-1</i> compound mutants. Four asterisks (****) indicate a highly significant association (the two-tailed P value is less than 0.0001) between groups and/or outcomes as measured by Fisher's exact test. Two asterisks (**) indicate a statistically significant association (P = 0.0242).