Iron-Catalyzed, Chelation-Induced Remote C–H Allylation of Quinolines via 8‑Amido Assistance

An iron-catalyzed, 8-amido-enabled regiodivergent C–H allylation of quinolines is described. This reaction represents a rare example of chelation-induced geometrically inaccessible C–H functionalization, allowing for the highly regio- and stereoselective preparation of either the C5- or the C4-allylated quinoline scaffolds regiocontrolled by the catalytic systems