Heterogeneity in the response to inhibitors of STAT3 activation.

<p>Cal33 cells were exposed to Pyridone-6 (A&B) or STATTIC (C&D) at the indicated concentrations for 3 hours prior to stimulation with 50 ng/ml of IL-6. A) Inhibition by Pyridone-6. Log scaled distributions are plotted to normalize CV. B) Three heterogeneity parameters were calculated from the linear scaled data, DIV (red), nNRM (green) and %OL (blue). C) Log scaled distributions of inhibition by Stattic. D) The same three heterogeneity parameters are plotted for the linear scaled distributions of Stattic inhibition. The vertical dashed lines indicate the IC50 for the compounds calculated from the well-averaged signal intensities.