Iterative refinements of the biclusters identified by biDCG.

<p>The biclustering method biDCG was applied on two synthetic expression matrices designed to represent 10 biclusters, either constant (left panel, A), or additive (right panel, B), both with overlap of 8 between the biclusters (see text for details). The initial biclusters (shown as white boxes) defined by simple applications of DCG on the whole matrix do not match correctly with the biclusters that were implanted; for example, DCG identified 11 biclusters in the constant cluster case (panel A). Iterative refinements of the biclusters however lead to the correct identification of all 10 reference biclusters, as shown as green sub matrices.