FTY720 suppresses Kasumi-1 xenograft tumor growth.

<p>Nude mice (7 or 8 mice per group) with Kasumi-1 tumor were injected intraperitoneally with vehicle (5% glucose), Ara C (5 mg/kg, positive control) or FTY720 (1 mg/kg, 5 mg/kg) for 21days. (A) Tumor volumes were measured every three days. Data are expressed as mean volumes. *P<0.05. (B, C) Animals were sacrificed at day 21, and tumors were excised and weighed. Average (B) and representative (C) results are shown. *P<0.05. **P<0.01 (D) TUNEL assay was used to detect apoptotic cells in tumors of Kasumi-1 Xenograft models treated with vehicle, Ara-C (5 mg/kg), or FTY720 (5 mg/kg).