Robust fibrotic response in the absence of innate immune receptors or ligands.

<p>Hydroxyproline (OH-proline) content assessed in lung homogenates of mice 60 days after saline (NaCl) or silica (SiO₂) instillation in wild-type (WT), IL-1R- (<b>A</b>), ASC- (<b>B</b>), NALP3- (<b>C</b>), IL-1β- (<b>D</b>), TRIF- (<b>E</b>), TLR2/4- (<b>F</b>), TLR3- (<b>G</b>), γδTCR- (<b>H</b>), IL-23p19- (<b>I</b>) knockout (KO) mice. Bars represent means ± SEM (n = 3–5). These results were treated statistically by a t- test. ns indicates no statistically significant difference and ** = p<0.01 indicates statistically significant difference between values measured in silica-treated WT and silica-treated KO mice.