The effect of p<i>2TA</i> peptide on Cyclin D1 expression in mouse intestine.

<p>Expression of Cyclin D1 in mouse intestine: a–h) overview, i–p) details. a–d, i–l) A/J mice; e–h, m–p) BALB/c mice; a,e,i,m) sham irradiated controls; b,f,j,n) mice treated with p<i>2TA</i> peptide six days before tissue harvest; c,g,k,o) mice exposed to 8 Gy gamma rays total body irradiation seven days before the sacrifice; d,h,l,p) mice exposed to 8 Gy gamma rays that received 5 mg/kg p<i>2TA</i> peptide 24 hours after radiation exposure. In irradiated mice (c,g,k,o) villus integrity is disrupted, their crypts show disorganization, and very little Cyclin D1 staining can be observed outside the crypts. Intestines of irradiated mice that were treated with p<i>2TA</i> peptide 24 h later show a more normal morphology with respect to villus height and crypt appearance; they also show more numerous CD1 positive cells inside villi.