Temporal organization, phase relationship and amplitude of <i>Per2, Bmal1 and Dbp</i> expression in the SCN, CEAl and DG.

<p>The double plotted line graphs show relative mRNA levels across 12 <i>zeitgeber</i> times fitted with a 24-h sine wave between the SCN, CEAl, and DG for <i>Per2</i> (a), <i>Bmal1</i> (b), and <i>Dbp</i> (c). The sine waves were fit to the data grouped in consecutive 2-h intervals as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103309#pone-0103309-g001" target="_blank">figures 1</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103309#pone-0103309-g003" target="_blank">3</a>. The phase relationship between the SCN, CEAl, and DG for each of the genes is depicted in the 24-h circular diagrams and the amplitude between these regions in the bar graphs. Asterisk indicates statistical significance (<i>p</i><.05) as follows: *: CEAl compared to all other regions.