Induction of ER stress in mice activates the hepatic AP-1 complex.

<p>Relative hepatic mRNA expression of G<i>rp78/Bip</i>, <i>Chop</i>, <i>cFos</i>, <i>Fra-1</i>, <i>cJun</i>, and <i>JunD</i> in mice treated with tunicamycin (Tm) at doses of A) 2 mg/kg for 6 hours, B) 2 mg/kg for 72 hours, or C) 0.5 mg/kg over 5 days. Hepatic protein expression of total and phosphorylated CFOS and CJUN in mice treated with Tm at doses of D) 2 mg/kg for 6 hours, E) 2 mg/kg for 72 hours, or F) 0.5 mg/kg over 5 days. Quantitative PCR shown as mean (n = 6) ± SD. * p<0.05 vs vehicle-treated. Representative Western blot of pooled samples, n = 2–3.