<p>Multiple pockets per protein are considered, but one is shown here for simplicity.</p
A powerful early approach to evaluating the druggability of proteins involved determining the hit ra...
National audienceThis long abstract discusses a strategy for modeling protein flexibility which is b...
ABSTRACT: Druggability assessment of a target protein has emerged in recent years as an important co...
Advances reported over the last few years and the increasing availability of protein crystal structu...
Target selection is a critical step in the majority of modern drug discovery programs. The viability...
<p>Targets are from <i>Huang and Jacobson</i><a href="http://www.ploscompbiol.org/article/info:doi/1...
<p>The “Structures” column provides the number of unique PDB entries represented, and “Proteins” rep...
Predicting protein pocket’s ability to bind drug-like molecules with high affinity, i.e. druggabilit...
Predicting protein druggability is a key interest in the target identification phase of drug discove...
An efficient molecular simulation methodology has been developed for the evaluation of the druggabil...
<p>Pockets found where a bound ligand would disrupt a protein-protein interaction are shown in the b...
Nowadays, it is well established that most of the human diseases which are not related to pathogen i...
<p>A 2D histogram showing all pockets found in the mammalian structural proteome with initial volume...
Molecular surfaces of proteins and other biomolecules, while modeled as smooth analytic interfaces s...
<p>Volumes of surface pockets are shown from conformations generated with no biasing potential (<i>l...
A powerful early approach to evaluating the druggability of proteins involved determining the hit ra...
National audienceThis long abstract discusses a strategy for modeling protein flexibility which is b...
ABSTRACT: Druggability assessment of a target protein has emerged in recent years as an important co...
Advances reported over the last few years and the increasing availability of protein crystal structu...
Target selection is a critical step in the majority of modern drug discovery programs. The viability...
<p>Targets are from <i>Huang and Jacobson</i><a href="http://www.ploscompbiol.org/article/info:doi/1...
<p>The “Structures” column provides the number of unique PDB entries represented, and “Proteins” rep...
Predicting protein pocket’s ability to bind drug-like molecules with high affinity, i.e. druggabilit...
Predicting protein druggability is a key interest in the target identification phase of drug discove...
An efficient molecular simulation methodology has been developed for the evaluation of the druggabil...
<p>Pockets found where a bound ligand would disrupt a protein-protein interaction are shown in the b...
Nowadays, it is well established that most of the human diseases which are not related to pathogen i...
<p>A 2D histogram showing all pockets found in the mammalian structural proteome with initial volume...
Molecular surfaces of proteins and other biomolecules, while modeled as smooth analytic interfaces s...
<p>Volumes of surface pockets are shown from conformations generated with no biasing potential (<i>l...
A powerful early approach to evaluating the druggability of proteins involved determining the hit ra...
National audienceThis long abstract discusses a strategy for modeling protein flexibility which is b...
ABSTRACT: Druggability assessment of a target protein has emerged in recent years as an important co...
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