Pre-depletion of pDC leads to higher levels of HIV-1 replication.

<p>(<b>A</b>) Plasma HIV-1 RNA levels from HIV-R3A infected mice (genome copy#×log10/ml) are summarized. isotype+R3A, <i>n</i> = 9; 15B+R3A, <i>n</i> = 12. (<b>B</b>) Plasma HIV-1 RNA levels from JR-CSF infected mice at 2 wpi are summarized. isotype+JR-CSF, <i>n</i> = 12; 15B+JR-CSF, <i>n</i> = 12. (<b>C</b>) Immunohistochemistry staining for p24 positive cells in the spleen of mock or HIV-R3A infected mice. (<b>D</b>) Representative FACS plots for p24 positive CD4 T cells in the spleen of mock or JRCSF infected mice at 3 wpi. (<b>E</b>) Summarized data of D. isotype+JR-CSF, <i>n</i> = 7; 15B+JR-CSF, <i>n</i> = 7. Bars in dot graphs indicate median value. * indicates p<0.05.