Add to ORKGA wide variety of natural products have been isolated from Didemnum species of ascidians, and a survey of such compounds is presented. The didemnaketals are the only spiroacetal containing natural products to be elaborated by this genus, with didemnaketal A showing the greatest activity against HIV-1 protease. General synthetic approaches to the spiroacetal moiety are discussed, and then applied in retrosynthetic analyses of the spiroacetal portion of didemnaketal A. Synthesis towards this spiroacetal portion is reported, with the products being characterised by detailed 2D NMR spectroscopy and other methods. The relative stereochemistry at C12, C14, C16, C18 and C20 in the natural product is established. Further extensions of the synthesis...
This thesis presents an effort to contribute to the discovery and development of structurally and m...
The didemnins, isolated from a marine tunicate displayed diverse bioactivity namely antiviral, antit...
The didemnins are a class of macrocyclic depsipeptides that were isolated from a Caribbean tunicate ...
In continuation of our ongoing efforts to identify bioactive compounds from Red Sea marine organisms...
[GRAPHICS] The stereocontrolled synthesis of (2S,4R,6R,8S,10S,1'R,1"R)-2(acetylhydroxymethyl)-4, 10-...
Didemnaketals are rare terpenoid class reported only in the marine ascidian Didemnum species. They p...
AbstractDidemnaketals are rare terpenoid class reported only in the marine ascidian Didemnum species...
The chemical investigation of the crude extract of an ascidian of the genus Didemnumled to the isola...
251 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1983.The didemnins (shown below), ...
Didemnin B is a metabolite produced by a marine organism called a tunicate or sea squirt as a defens...
Total synthesis of the proposed structure of didemnaketal B has been accomplished. The C7–C21 spiroa...
The didemnins are a group of novel cyclodepsipeptides isolated from marine tunicates. All didemnins ...
The structures, origins and biological activities of marine-derived compounds incorporating a spiroa...
The didemnins are a class of depsipeptides which were isolated from a marine tunicate. Most didemnin...
The tamandarins are a class of naturally occurring cyclic depsipeptides isolated from a Brazilian as...
This thesis presents an effort to contribute to the discovery and development of structurally and m...
The didemnins, isolated from a marine tunicate displayed diverse bioactivity namely antiviral, antit...
The didemnins are a class of macrocyclic depsipeptides that were isolated from a Caribbean tunicate ...
In continuation of our ongoing efforts to identify bioactive compounds from Red Sea marine organisms...
[GRAPHICS] The stereocontrolled synthesis of (2S,4R,6R,8S,10S,1'R,1"R)-2(acetylhydroxymethyl)-4, 10-...
Didemnaketals are rare terpenoid class reported only in the marine ascidian Didemnum species. They p...
AbstractDidemnaketals are rare terpenoid class reported only in the marine ascidian Didemnum species...
The chemical investigation of the crude extract of an ascidian of the genus Didemnumled to the isola...
251 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1983.The didemnins (shown below), ...
Didemnin B is a metabolite produced by a marine organism called a tunicate or sea squirt as a defens...
Total synthesis of the proposed structure of didemnaketal B has been accomplished. The C7–C21 spiroa...
The didemnins are a group of novel cyclodepsipeptides isolated from marine tunicates. All didemnins ...
The structures, origins and biological activities of marine-derived compounds incorporating a spiroa...
The didemnins are a class of depsipeptides which were isolated from a marine tunicate. Most didemnin...
The tamandarins are a class of naturally occurring cyclic depsipeptides isolated from a Brazilian as...
This thesis presents an effort to contribute to the discovery and development of structurally and m...
The didemnins, isolated from a marine tunicate displayed diverse bioactivity namely antiviral, antit...
The didemnins are a class of macrocyclic depsipeptides that were isolated from a Caribbean tunicate ...