Nod1 and Nod2 are not essential for the resistance to polymicrobial sepsis.

<p>Sepsis was induced in WT, <i>Nod1</i>- and <i>Nod2</i>-deficient mice (WT, <i>Nod1</i>^−/− and <i>Nod2</i>^−/−, respectively) using CLP model. The survival curve was observed up to 10 days after the induction of a) non-severe (NS), b) moderate (M), c) severe (S) sepsis or d) after the intraperitoneal inoculation of 1.4×10⁶ cecal-isolated bacteria per mice. The results are expressed as percentage of survival and were analyzed by the Mantel-Cox log-rank test. The graphs represent the mean of the results of two or three independent experiments. <i>N = 5 to 6</i> per experiment.