Molecular changes following treatment of KNS42 pediatric glioblastoma cells with PI-103.
- Nada M. S. Al-Saffar (454143)
- Lynley V. Marshall (607343)
- L. Elizabeth Jackson (607344)
- Geetha Balarajah (607345)
- Thomas R. Eykyn (454146)
- Alice Agliano (607346)
- Paul A. Clarke (607347)
- Chris Jones (25458)
- Paul Workman (54973)
- Andrew D. J. Pearson (373289)
- Martin O. Leach (454145)
Publication date
August 2014
DOIAbstract
<p>(A) Representative flow cytometry analysis histograms showing cell cycle distribution of cells with vehicle treatment (DMSO, control, light grey), or following treatment with PI-103 (5×GI<sub>50</sub>, dark grey) at 8, 12, 24 or 48 hours post treatment. (B) Representative Western blots showing inhibition of the PI3K signaling pathway as indicated by decreased phosphorylation of AKT (Ser473) and RPS6 (Ser240/244) at selected time points post treatment with PI-103 (5×GI<sub>50</sub>).</p
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