<p>No significant increase in maximal efficacy to nicotine or acetylcholine. Statistically significant differences (p≤0.05) are identified by *.</p
<div><p>Nicotine leads to both activation and desensitization (inactivation) of nicotinic acetylchol...
<p><b>(A)</b> 14-day pumps filled with 200 mg/ml nicotine were placed in the backs of EAE mice at da...
<p>The percentage of time spent in the open versus closed arms (A) and the number of entries into op...
<p>A slight but insignificant change to the sensitivity to nicotine was observed in the β-arrestin2 ...
<p>Male CaMKIV +/+ and +/− mice develop a significant preference for nicotine (0.5 mg/kg, s.c.); how...
<p><b>A</b>) P20 amplitude following nicotine and nicotine receptor antagonists. Assessment of the e...
<p>The specificity of nicotine binding to antisera collected from TCCnic-12 immunized mice was deter...
<p>Weight changes were recorded and compared between vehicle (DMSO, n = 3 at all time points) and CS...
Testing genetically engineered mice in a reliable nicotine self-administration procedure could provi...
<p>Panel A shows responses of a cell to various concentrations of ACh and Panel B shows the response...
BACKGROUND and AIMS: We previously showed that intestinal inflammation is reduced by electrical stim...
Rationale Testing genetically engineered mice in a reliable nicotine self-administration procedure c...
<p>(A) Antinociceptive responses in wt and <i>lynx1</i>KO mice after I.P. injections of saline (n = ...
<p>This shows a representative normalized CT response in a TRPM5 KO mouse in which the tongue was fi...
<p>(A) control vs. 20 mg/kg cocaine; (B) control vs. nicotine +2 mg/kg cocaine; (C) 2 mg/kg cocaine ...
<div><p>Nicotine leads to both activation and desensitization (inactivation) of nicotinic acetylchol...
<p><b>(A)</b> 14-day pumps filled with 200 mg/ml nicotine were placed in the backs of EAE mice at da...
<p>The percentage of time spent in the open versus closed arms (A) and the number of entries into op...
<p>A slight but insignificant change to the sensitivity to nicotine was observed in the β-arrestin2 ...
<p>Male CaMKIV +/+ and +/− mice develop a significant preference for nicotine (0.5 mg/kg, s.c.); how...
<p><b>A</b>) P20 amplitude following nicotine and nicotine receptor antagonists. Assessment of the e...
<p>The specificity of nicotine binding to antisera collected from TCCnic-12 immunized mice was deter...
<p>Weight changes were recorded and compared between vehicle (DMSO, n = 3 at all time points) and CS...
Testing genetically engineered mice in a reliable nicotine self-administration procedure could provi...
<p>Panel A shows responses of a cell to various concentrations of ACh and Panel B shows the response...
BACKGROUND and AIMS: We previously showed that intestinal inflammation is reduced by electrical stim...
Rationale Testing genetically engineered mice in a reliable nicotine self-administration procedure c...
<p>(A) Antinociceptive responses in wt and <i>lynx1</i>KO mice after I.P. injections of saline (n = ...
<p>This shows a representative normalized CT response in a TRPM5 KO mouse in which the tongue was fi...
<p>(A) control vs. 20 mg/kg cocaine; (B) control vs. nicotine +2 mg/kg cocaine; (C) 2 mg/kg cocaine ...
<div><p>Nicotine leads to both activation and desensitization (inactivation) of nicotinic acetylchol...
<p><b>(A)</b> 14-day pumps filled with 200 mg/ml nicotine were placed in the backs of EAE mice at da...
<p>The percentage of time spent in the open versus closed arms (A) and the number of entries into op...