Effects of conditional deletion of <i>Fgfr1</i> in <i>Hyp</i> osteocytes on bone structure in 6-week-old mice.

<p>Representative μCT 3D images of (A) whole femur segital section, (B) the distal femoral metaphyses, and (C) femoral midshaft diaphyses in four genotypes of mice. Compared with control mice, <i>Fgfr1</i>^Dmp1-cKO-null mice had normal bone structure. However, <i>Hyp</i> mice showed considerably shorter femur length, less trabecular bone volume, and thinner cortical thickness, compound <i>Hyp</i>;<i>Fgfr1</i>^Dmp1-cKO-null mice displayed intermediate femur length and cortical thickness between control and <i>Hyp</i> mice, but no recovery was found in trabecular bone volume. Data are mean ± S.D. from 5–6 individual mice. Values sharing the same superscript in A, B, and C are not significantly different at <i>P</i><0.05.