Functional analysis of post-eclosion HR differential expression.

<p>(A) The top-scoring KEGG (square) and GO-BP (circle) annotations for up- and down-regulated genes are shown. Down-regulated genes are colored green and are highly enriched for DNA replication, cell cycle and DNA repair. Up-regulated genes are colored red and relate primarily to development and metabolism. In both cases, more intensive color indicates greater fold-enrichment [ranges: (−1.36)–(−4.61); 1.57–4.84] and size reflects the number of genes identified (4–195). (B) DAVID <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103292#pone.0103292-Huangda1" target="_blank">[11]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103292#pone.0103292-Huangda2" target="_blank">[12]</a>-identified KEGG <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103292#pone.0103292-Kanehisa1" target="_blank">[14]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103292#pone.0103292-Kanehisa2" target="_blank">[15]</a> and Panther <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103292#pone.0103292-Mi1" target="_blank">[16]</a> signaling pathway enrichment of genes differentially expressed in post-eclosion AF. The number of differentially expressed pathway genes is plotted and the total number of pathway genes is indicated below each pathway name (HH = Hedgehog, Jk-ST = Jak-STAT, PhosIn = Phosphatidylinositol, TGFB = TGF-beta, Cadh = Cadherin, Ins/IGF = Insulin/IGF).