TolB depletion increases <i>P. aeruginosa</i> sensitivity to polymyxins in a killing assay.

<p>Survival of PAO1 wild-type cells (filled circles) and TolB-deficient mutant cells (open diamonds), obtained as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103784#pone-0103784-g003" target="_blank">Figure 3A</a>, after 1-h treatment with 4, 1 or 0.25 mg/L of colistin (left panel), or 2, 0.5 or 0.125 mg/L of polymyxin B (right panel). Values are expressed as percent survival compared to untreated cells, and the results represent the mean (± SD) of three independent experiments. **, P<0.01 (one-way ANOVA).