Body weight change in mice used in CPP testing.

<p>Mean weight (±SEM) on days −10 to −1 prior to euthanasia relative to weight observed on day −14 in mice in the main CPP study. Weights in tumour-bearing mice significantly declined over the final 7 study days compared to control groups (‘Group (Cancer vs Control)×Time’, p = 0.001), with no apparent effect of morphine.