Ethanol Suppresses <i>PGC-1α - Figure 8 </i> Expression by Interfering with the cAMP-CREB Pathway in Neuronal Cells

<p>Dose-dependent effect of ethanol on the expression levels of PGC-1α, CREB, and p-CREB in human fetal brain neural stem cell-derived primary neurons. The primary neuronal cells were incubated with various concentrations of ethanol for 24 hrs, and after incubation with ethanol, the cells lysates were analyzed by Western blot to determine expression levels of PGC-1α, CREB, and p-CREB (Panel A). β-actin was used as loading control. The protein density in each Western blot was quantitatively analyzed, and is shown in Panels B and C. Mean ± SE, n = 3, *<i>P</i><0.05, **<i>P</i><0.01 <i>vs.</i> control.