Model for the role of DivIVA during sporulation.

<p>A sporulating <i>B. subtilis</i> cell is depicted using the same color scheme as in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004526#pgen-1004526-g001" target="_blank">Fig. 1A</a>. (A) FtsZ (red ring) initially assembles in the pre-divisional cell at mid-cell and recruits SpoIIE (blue ring); at this time, DivIVA (green arcs) pre-localizes as patches at the two cell poles to perform its role in chromosome anchoring. (B) FtsZ and SpoIIE redeploy to polar division sites. In addition to SpoIIE and the increased expression of <i>ftsZ</i>, this redeployment requires DivIVA in a manner that is independent of MinCD and RacA, but the molecular mechanism of which is unclear. (C) One of the polar FtsZ rings constricts, while the other is eventually disassembled. Sensing membrane invagination, DivIVA localizes to either side of the nascent asymmetric septum and then sequesters SpoIIE to the septum. Although DivIVA is initially on both sides of the forming polar septum, SpoIIE preferentially localizes to the forespore side. (D) Upon completion of polar septum formation, both DivIVA and SpoIIE persist preferentially on the forespore side of the polar septum. (E) SpoIIE is released into the forespore membrane. It is subsequently recaptured at the polar septum by a protein produced under the control of σ^F<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004526#pgen.1004526-Campo1" target="_blank">[29]</a>.