Meta-analysis plots of the progression-free and overall survival hazard ratios in individual trials.

<p>A is the forest plot and B, C, and D are the “filled” funnel plots of OS, DFS, and the unclear group, respectively. The meta-analysis displayed a significant effect in favor of a high volume. The pooled and filled results are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103910#pone-0103910-t002" target="_blank">Table 2</a>.