Airway responsiveness phenotype of BcA86 recombinant congenic strain

<p>. (A) Enhanced pause (Penh) in response to 15 mg/ml of methacholine was measured in A/J, C57BL/6J, BcA86 and BcA86 F1 mice. (n = 14 A/J, 12 C57BL/6J, 8 BcA86 and 28 BcA86F1). (B) Airway resistance of A/J, C57BL/6J and BcA86 strains in response to 25 mg/ml of methacholine. Resistance values were normalized by baseline readings and data is shown as the fold increase from baseline. Data are presented as mean ± SEM and statistical significance was calculated by one-way ANOVA and Bonferroni correction. n>5 per strain; _{*, **}, and _*** represent <i>p</i><0.05, <i>p</i><0.01, and <i>p</i><0.001, respectively.