Blockade of IL-36 signaling in vivo does not influence TNF-induced arthritis.

<p>Representative pictures and histological analyses of the hind paws of anti-IL36R and control-treated mice from (A) Hematoxylin and Eosin (H&E) stainings, inflammatory areas are indicated by the arrows; (B) Toluidinblue (TB) stainings, proteoglykan loss is indicated by arrows. (C) TRAP staining of osteoclasts. (D) Sera analysis for IL-8 and the transgene TNFα of the 8-week-old mice. Graphs represent the mean ± SEM (n = 8–9).