S14161 inhibited platelet aggregation more potently than LY249002.

<p>Gel-filtered human platelets (2.5×10⁸/mL) were preincubated for 10 minutes with different concentrations of LY249002 (10 µM, 20 µM and 40 µM) (A, B) or equal concentration of S14161 or LY249002. Platelet aggregation was initiated with collagen (2 µg/mL), thrombin (0.1 U/mL). The aggregation curves are the representatives of at least three individual experiments. Means ± standard errors of the mean of platelet aggregation percentage from three experiments are plotted in the bar charts; *P<0.05, **P<0.01 and ***P<0.001 as compared with control. N.S. means no significance (n = 3).