PTER-ITC alters PPARγ activity through p38 MAPK and JNK pathways.

<p>(A) PTER-ITC induces PPARγ expression through p38 MAPK and JNK pathways in MCF-7 and MDA-MB-231 cells. The experiment was performed in duplicate and yielded similar results. Histogram (bottom) shows relative band intensities normalized to the corresponding β-actin level, where the vehicle-treated group = 1. (B) Effects of p38 MAPK and JNK inhibitors on PTER-ITC-induced apoptosis in MCF-7 and MDA-MB-231 cells. Data are shown as mean ± SEM of three independent experiments. * and # indicate statistically significant difference with respect to vehicle-treated control and only PTER-ITC treated cells, respectively; <i>p</i><0.05.