Computational time overhead of the numerical solution of CME and SSA with respect to numerical solution of reduced model.

<p>Computational time overhead, as given by (34), required to solve the full CME (diamonds) and to perform 10³ SSA runs (squares) as compared to the computational time required in seconds to simulate the reduced order model, as the initial number of molecules for <i>E</i> and <i>S</i> vary from 5 to 100. The parameters values used for simulation are identical to those of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103521#pone-0103521-g003" target="_blank">Figure 3</a>.