<p>A. The exon 2 region of WT mice was not knockout and gene length was too long to have PCR product. The exon 2 region of EP4<sup>+/−</sup> mice was knockout and PCR product was 370 bp. B. PCR product of EP4<sup>Flox/Flox</sup> mice was 344 bp and WT mice was 243 bp.</p
<p>(A) RT-PCR results for PMO, PNA and2′Ome PS in <i>C3H</i> mice 48 hr after local intramuscular in...
<p>A. Schematic of the targeting construct of Zip4 showing the region of the Zip4 gene flanked by th...
<p>Quantitative RT-PCR of (A) <i>Ephx3</i>, (B) <i>Ephx1</i>, (C) <i>Ephx2</i>, and (D) <i>Ephx4</i>...
<p>(A) A 179 kb BAC clone containing the entire SNAP-23 gene was mutated by introducing loxP sites s...
<p>The mouse <i>Rfx2</i> gene is depicted approximately to scale from exon 6 onward (A). Below is sh...
<p>A–D: genotyping by PCR. Mice were screened by PCR analysis of tail DNA, using the primer pair p5:...
<p>A, Gene targeting strategy. Open box, <i>R26</i> exon 1; DT-A, diphtheria toxin expression casset...
<p>(A) Wild type (WT), floxed SLIRP and SLIRP knockout (KO) mouse SLIRP locus configurations. Floxed...
<p>A: Expression of EP4 in EP4<sup>+/−</sup> mouse GMCs was detected by western blot. B: Expression ...
<p>A) Targeting strategy for the <i>fgf22</i> knockout mouse. Schematic representations of the endog...
<p>(A) Floxed <i>Cyp26b1</i> locus showing position of primers (P1, P2, P3) used for genotyping. Lox...
<p>The generation of transgenic mice containing the <i>FXN-EGFP</i> genomic reporter construct in a ...
<p>(<b>a</b>) <i>Ptpn2</i> genomic locus and targeting design. (<b>b–c</b>) Southern blot analysis o...
(A) Gcm2 has five exons: exon 2 and 3 contain the DNA binding site (black box). At the targeting vec...
<p>PCR to detect the DOCK2 mutation was performed on tail DNA of all mice used in this study. Experi...
<p>(A) RT-PCR results for PMO, PNA and2′Ome PS in <i>C3H</i> mice 48 hr after local intramuscular in...
<p>A. Schematic of the targeting construct of Zip4 showing the region of the Zip4 gene flanked by th...
<p>Quantitative RT-PCR of (A) <i>Ephx3</i>, (B) <i>Ephx1</i>, (C) <i>Ephx2</i>, and (D) <i>Ephx4</i>...
<p>(A) A 179 kb BAC clone containing the entire SNAP-23 gene was mutated by introducing loxP sites s...
<p>The mouse <i>Rfx2</i> gene is depicted approximately to scale from exon 6 onward (A). Below is sh...
<p>A–D: genotyping by PCR. Mice were screened by PCR analysis of tail DNA, using the primer pair p5:...
<p>A, Gene targeting strategy. Open box, <i>R26</i> exon 1; DT-A, diphtheria toxin expression casset...
<p>(A) Wild type (WT), floxed SLIRP and SLIRP knockout (KO) mouse SLIRP locus configurations. Floxed...
<p>A: Expression of EP4 in EP4<sup>+/−</sup> mouse GMCs was detected by western blot. B: Expression ...
<p>A) Targeting strategy for the <i>fgf22</i> knockout mouse. Schematic representations of the endog...
<p>(A) Floxed <i>Cyp26b1</i> locus showing position of primers (P1, P2, P3) used for genotyping. Lox...
<p>The generation of transgenic mice containing the <i>FXN-EGFP</i> genomic reporter construct in a ...
<p>(<b>a</b>) <i>Ptpn2</i> genomic locus and targeting design. (<b>b–c</b>) Southern blot analysis o...
(A) Gcm2 has five exons: exon 2 and 3 contain the DNA binding site (black box). At the targeting vec...
<p>PCR to detect the DOCK2 mutation was performed on tail DNA of all mice used in this study. Experi...
<p>(A) RT-PCR results for PMO, PNA and2′Ome PS in <i>C3H</i> mice 48 hr after local intramuscular in...
<p>A. Schematic of the targeting construct of Zip4 showing the region of the Zip4 gene flanked by th...
<p>Quantitative RT-PCR of (A) <i>Ephx3</i>, (B) <i>Ephx1</i>, (C) <i>Ephx2</i>, and (D) <i>Ephx4</i>...
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