Three autoregulatory parameters derived from the transfer function.

<p>A) Step response, B) phase difference, and C) gain. Each colored line denotes an average parameter from each group. A) The dashed line is the unit step change to the transfer function, and the colored lines are responses derived from the transfer function for different groups. Both the step response and phase difference show that the best (quickest recovery from the step change and largest phase difference) dynamic cerebral autoregulation is displayed by the non-right-to-left shunt (non-RLS) group, and the worst (slowest recovery and smallest phase difference) is displayed by the large RLS group, whereas other groups are in between (statistical distribution of the parameters is shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0104849#pone-0104849-g002" target="_blank">Figure 2</a>).