CaMKIIβ KO mice have impaired cognitive function and nesting behavior.

<p>(<b>A</b>) None of the mice show a preference for two identical objects presented in the NOR training session. In the subsequent test session done after a 4 hour delay, the WT mice showed a preference for the novel object as indicated by increased D2 index, but the KO mice showed no preference for either object. (<b>B</b>) CaMKIIβ KO mice made a significantly lower quality nest compared to their littermates. (<b>C</b>) Representative photographs of the nests. Photographs on the bottom row are higher-power views of the nests at 24 h. *p<0.05, **p<0.01. Data are presented as means ±SEM. Number of mice per group is indicated on each graph.