Role of C3 in cell-death induced inflammation.

<p>(A, B) The total neutrophil (A) and monocyte (B) numbers in peritoneal cavity of WT C57BL/6 mice and C3-deficient mice 4 hours after i.p. injection of heat-shocked necrotic EL4 cells. (C, D) The total neutrophil (C) and monocyte (D) numbers in peritoneal cavity of WT C57BL/6 mice and C3-deficient mice 16 hours after i.p. injection of heat-shocked necrotic EL4 cells. (E, F) Myeloperoxidase activity in the liver (E) and serum levels of ALT (F) of mice challenged with i.p. injection of 300 mg/kg of Acetaminophen in C57BL/6 or C3 deficient mice. The data are combined results of 5 experiments and represented as means ±SEM (<i>n</i> = total number of mice from the multiple experiments for each group). * <i>P</i><0.05, NS, not significant versus WT groups. PBS groups, WT mice received i.p. PBS.