Role of PAR2 in cell-death induced inflammation.

<p>(A, B) The total neutrophil (A) and monocyte (B) numbers in peritoneal cavity of WT C57BL/6 mice and protease-activated receptor 2 (PAR2)-deficient mice 4 hours after i.p. injection of heat-shocked necrotic EL4 cells. (C, D) The total neutrophil (C) and monocyte (D) numbers in peritoneal cavity of WT C57BL/6 mice and µMT mice 16 hours after i.p. injection of heat-shocked necrotic EL4 cells. The data are combined results of 5 experiments and represented as means ±SEM (<i>n</i> = total number of mice from the multiple experiments for each group). (E, F, G) The total neutrophil (E) and monocyte (F) numbers in hepatic nonparenchymal cell suspension and serum levels of ALT (G) of mice challenged with i.p. injection of 300 mg/kg of acetaminophen in WT C57BL/6 or protease-activated receptor 2 (PAR2)-deficient mice. The data are combined results of 4 experiments and represented as means ±SEM (<i>n</i> = total number of mice from the multiple experiments for each group). * <i>P</i><0.05, NS; not significant versus WT groups. PBS groups; WT mice received i.p. PBS.