Group comparison of bulbar and limb phenotype patient subgroups versus healthy controls.

<p>Wholebrain group-mean of VBI images projected on generic brain (c) and Maximum Intensity Projection (MIP) of significantly different regions (d, e, f). The patterns of MRI intensity change in bulbar (a) and limb (b) subgroups significantly differ despite no significant differences in age, sex or ALSFRS-R score between groups. Coronal (d), sagittal (e) and axial (f) MIPs illustrate apparently more widespread involvement of cerebral white matter in bulbar-onset ALS. Inference was done using Threshold Free Cluster Enhancement (10000 permutations) und Family-wise error rate correction for multiple comparisons. Color spectrum giving p-value indication (g).