Evaluation of NP specific IgA in mucosal lavages.

<p>NP-specific IgA titers measured by ELISA in nasal (NL) and BAL lavages of BALB/c mice immunized with two doses of rNP (10 µg/dose) alone or co-administered with c-di-AMP (10 µg/dose) by intranasal route at an interval of 3 weeks. Control animals received PBS. Results are expressed as NP specific IgA titer. The S.E.M. is indicated by vertical lines. Differences were statistically significant at p<0.001 (***) and p<0.01 (**), compared with the titers in mice immunized with rNP alone.