Representative images of DKK1 and β-catenin immunohistochemical staining in human cartilage tumors.

<p>(<b>A</b>) The expression profiles of DKK1 staining are shown in human cartilage tumors. Negative cytoplasmic DKK1 staining was observed in enchondroma (<b>a</b>). A well-differentiated (Grade I) chondrosarcoma with negative cytoplasmic DKK1 expression (<b>b</b>). A moderately differentiated (Grade II) chondrobsarcoma with weak cytoplasmic DKK1 expression (<b>c</b>). A poorly differentiated (Grade III) chondrosarcoma with prominent and strong cytoplasmic DKK1 expression (<b>d</b>). (<b>B</b>) The expression patterns of β-catenin are presented in human cartilage tumors. Enchondroma with negative β-catenin immunostaining (<b>a</b>). Weak (<b>b</b>), moderate (<b>c</b>), and strong (<b>d</b>) nuclear immunostaining of β-catenin accumulation were detected in chondrosarcoma, respectively. Original magnification×400.