<p><b>A)</b> Analysis of transcriptional changes in islets after 24 hours of Sox17 overexpression by microarray. The heat map highlights the Sox17-regulated transcripts (upregulated genes in red, downregulated genes in blue, n = 3 per genotype). <b>B–D)</b> Quantitative-RTPCR validation of transcripts that were up- or down-regulated in response to Sox17 including Glp-1 receptor (Glp1R), protein kinase C isoform a (Prkca), Reticulon 1 (Rtn1), all of which are known regulators of secretory pathway. <b>E)</b> Schematic representation of Sox17-regulated factors and their known involvement in the insulin processing and secretory pathways. Genes that were upregulated by Sox17 expression are shown in red, and those that were down regulated are sho...
To investigate the role of the Sry/hydroxymethylglutaryl box (Sox) transcription factors in the deve...
<p><b>A–B)</b> Non-fasting and fasting states of Sox17-paLOF and control mice at 1.5 years of age sh...
<p>A) The beta-cell specific GLP-1 response consensus network, annotated with the top enriched KEGG ...
<div><p>SOX17 is a key transcriptional regulator that can act by regulating other transcription fact...
<p><b>A, B)</b> Tetracycline-regulated expression of Sox17 in Pdx1t<sup>TA/+</sup> animals. Sox17 le...
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the...
<p><b>A, B)</b> There were no statistically significant differences in non-fasting blood glucose lev...
<p>(A) Gene expression (blue) and H3K4me<sup>3</sup> level (red) profiles for SOX17. The horizontal ...
Pancreatic beta-cells (β-cells) are essential for the maintenance of blood glucose homeostasis, as t...
The transcription factor Sox4 has been proposed to underlie the increased type 2 diabetes risk linke...
The HMG box transcription factor Sox9 plays a critical role in progenitor cell expansion during panc...
Objective: G protein-coupled receptor (GPCR) signaling regulates insulin secretion and pancreatic β ...
Normal glucose homeostasis is characterized by appropriate insulin secretion and low HbA1c. Gene exp...
OBJECTIVES—To identify, map, clone, and functionally vali-date a novel mouse model for impaired gluc...
To investigate the role of the Sry/hydroxymethylglutaryl box (Sox) transcription factors in the deve...
To investigate the role of the Sry/hydroxymethylglutaryl box (Sox) transcription factors in the deve...
<p><b>A–B)</b> Non-fasting and fasting states of Sox17-paLOF and control mice at 1.5 years of age sh...
<p>A) The beta-cell specific GLP-1 response consensus network, annotated with the top enriched KEGG ...
<div><p>SOX17 is a key transcriptional regulator that can act by regulating other transcription fact...
<p><b>A, B)</b> Tetracycline-regulated expression of Sox17 in Pdx1t<sup>TA/+</sup> animals. Sox17 le...
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the...
<p><b>A, B)</b> There were no statistically significant differences in non-fasting blood glucose lev...
<p>(A) Gene expression (blue) and H3K4me<sup>3</sup> level (red) profiles for SOX17. The horizontal ...
Pancreatic beta-cells (β-cells) are essential for the maintenance of blood glucose homeostasis, as t...
The transcription factor Sox4 has been proposed to underlie the increased type 2 diabetes risk linke...
The HMG box transcription factor Sox9 plays a critical role in progenitor cell expansion during panc...
Objective: G protein-coupled receptor (GPCR) signaling regulates insulin secretion and pancreatic β ...
Normal glucose homeostasis is characterized by appropriate insulin secretion and low HbA1c. Gene exp...
OBJECTIVES—To identify, map, clone, and functionally vali-date a novel mouse model for impaired gluc...
To investigate the role of the Sry/hydroxymethylglutaryl box (Sox) transcription factors in the deve...
To investigate the role of the Sry/hydroxymethylglutaryl box (Sox) transcription factors in the deve...
<p><b>A–B)</b> Non-fasting and fasting states of Sox17-paLOF and control mice at 1.5 years of age sh...
<p>A) The beta-cell specific GLP-1 response consensus network, annotated with the top enriched KEGG ...