Increase of pancreatic islet size in leptin-deficient mice is depending on FTO.

<p>a) Haematoxylin and eosin staining on paraffin sections of the pancreas for all 4 genotypes. b) Immunofluorescence staining for insulin (red) and glucagon (green) on pancreas sections. Nuclei are stained with DAPI. Scale = 100 µm. c) Area of beta cells in relation to full pancreas section area. d) Number of islets of Langerhans which were found on sections categorized into 3 groups of size. Pancreas were taken from 30 weeks old female mice (n = 5, 6, 7, 5). All data are presented as mean. Error bars indicate the SEM.