The M2 activation profile in the liver during infection results from differential expression of various M2 genes by distinct subpopulations of infiltrating leukocytes.

<p>Quantitative real-time PCR analysis of: <b>A</b>. <i>Arg1, Rtlna</i>, <i>Chi3l3</i>, <i>Tnf</i>, and <i>Nos2</i> mRNA in whole liver, comparing naïve (N) to infected (I) mice. <b>B</b>. <i>Arg1, Rtlna</i>, <i>Chi3l3</i> mRNA in the indicated cell populations, FACS-purified from livers of infected mice, presented as fold increase relative to expression in blood Ly6C^hi cells from naive mice. <b>C</b>. <i>Tnf</i>, and <i>Nos2</i> mRNA in cell populations as described in B. The data represent mean values ± SEM of data from 2 experiments, in each of which tissue or cells were pooled from 2 or more animals.