CAV1 knockdown inhibited HGF evoked activation of c-Met signaling pathway.

<p><b>A.</b> SNU-449 cells transfected with CAV1-siRNA or NT-siRNA for 72 h, stimulated with HGF for 30 min were subjected to WB analysis with indicated antibodies. Calnexin was used as a loading control. <b>B.</b> The graph depicting results from densitometry quantitation of CAV1 band which was normalized to calnexin. Error bars represent S.E. (n = 5). Band intensities of phospho-Met and p-MAPK were quantified by densitometry and normalized to c-Met and MAPK, respectively (n = 3). Values from NT-siRNA were set at 1. ANOVA was used in comparison of groups. (*<i>p</i><0,05, NS: not significant).