<div><p>Discovery of transmission blocking compounds is an important intervention strategy necessary to eliminate and eradicate malaria. To date only a small number of drugs that inhibit gametocyte development and thereby transmission from the mosquito to the human host exist. This limitation is largely due to a lack of screening assays easily adaptable to high throughput because of multiple incubation steps or the requirement for high gametocytemia. Here we report the discovery of new compounds with gametocytocidal activity using a simple and robust SYBR Green I- based DNA assay. Our assay utilizes the exflagellation step in male gametocytes and a background suppressor, which masks the staining of dead cells to achieve healthy signal to no...
Item does not contain fulltextOBJECTIVES: The development of drugs to reduce malaria transmission is...
The success achieved in controlling malaria in recent years [1, 2], has caused a focal shift to elim...
Objectives: Plasmodium gametocytes, responsible for malaria parasite transmission from humans to mos...
Discovery of transmission blocking compounds is an important intervention strategy necessary to elim...
Objectives: As most available antimalarial drugs are ineffective against the Plasmodium falciparum t...
Objectives: As most available antimalarial drugs are ineffective against the Plasmodium falciparum t...
In response to a call for the global eradication of malaria, drug discovery has recently been extend...
In response to a call for the global eradication of malaria, drug discovery has recently been extend...
Objectives: As most available antimalarial drugs are ineffective against the Plasmodium falciparum t...
Recent success in the global reduction campaign against malaria has resulted in the possibility that...
BACKGROUND: Current anti-malarial drugs have been selected on the basis of their activity against th...
open11siThis work was supported by the Global Health Program of the Bill & Melinda Gates Foundation....
OBJECTIVES: Plasmodium gametocytes, responsible for malaria parasite transmission from humans to mos...
Item does not contain fulltextOBJECTIVES: Plasmodium gametocytes, responsible for malaria parasite t...
Abstract Background Blocking malaria transmission is an important step in eradicating malaria. In th...
Item does not contain fulltextOBJECTIVES: The development of drugs to reduce malaria transmission is...
The success achieved in controlling malaria in recent years [1, 2], has caused a focal shift to elim...
Objectives: Plasmodium gametocytes, responsible for malaria parasite transmission from humans to mos...
Discovery of transmission blocking compounds is an important intervention strategy necessary to elim...
Objectives: As most available antimalarial drugs are ineffective against the Plasmodium falciparum t...
Objectives: As most available antimalarial drugs are ineffective against the Plasmodium falciparum t...
In response to a call for the global eradication of malaria, drug discovery has recently been extend...
In response to a call for the global eradication of malaria, drug discovery has recently been extend...
Objectives: As most available antimalarial drugs are ineffective against the Plasmodium falciparum t...
Recent success in the global reduction campaign against malaria has resulted in the possibility that...
BACKGROUND: Current anti-malarial drugs have been selected on the basis of their activity against th...
open11siThis work was supported by the Global Health Program of the Bill & Melinda Gates Foundation....
OBJECTIVES: Plasmodium gametocytes, responsible for malaria parasite transmission from humans to mos...
Item does not contain fulltextOBJECTIVES: Plasmodium gametocytes, responsible for malaria parasite t...
Abstract Background Blocking malaria transmission is an important step in eradicating malaria. In th...
Item does not contain fulltextOBJECTIVES: The development of drugs to reduce malaria transmission is...
The success achieved in controlling malaria in recent years [1, 2], has caused a focal shift to elim...
Objectives: Plasmodium gametocytes, responsible for malaria parasite transmission from humans to mos...