Regions of longitudinal changes in white matter microstructure between baseline and follow-up scan in MHE patients.

<p>Mean FA values were directly obtained from clusters showing significant changes between baseline and follow-up scan. Z_max values represent TFCE FWE-corrected clusters (p<.05). Multiple brain atlases implemented in FSL were used to define anatomical regions of significant clusters after statistical comparisons. Diffusivity values corresponding to each cluster with significant longitudinal changes are represented as differences (baseline – follow up) in MD, D_ax and D_rad (mm²/s) multiplied by a factor of 10⁶. Boldfaced diffusivity values with “*” represent significant differences (<i>P</i><.05, Bonferroni-adjusted) between baseline and follow-up scans.</p><p>Abbreviations: FA, fractional anisotropy; MNI, Montreal Neurological Institute; SD, standard deviation; DTI, diffusion-tensor imaging; D_ax, axial diffusivity; MD, mean diffusivity; D_rad, radial diffusivity; BA, Brodmann area; TFCE, threshold-free cluster enhancement; FWE, family-wise error.</p><p>Regions of longitudinal changes in white matter microstructure between baseline and follow-up scan in MHE patients.