<p>DCs were isolated from C57BL/6 and NOD pancreas at an age of 5 weeks. DCs were cultured for 18 h in the presence of LPS or under control conditions (PBS). IL-6, IL-10, IL-12p70 and TNF-α were measured in the supernatant. Bars are represented as median with IQR with N = 4 of 10 pooled mice per sample, P-values were determined by Mann-Whitney U test; *p<0.05.</p
<p>Unfractionated splenocytes from WT (□) and RasGRP4-null (■) mice were incubated for 24 or 48 h in...
<p>A) The DC were generated from DBA/1J mice and cultured for 18 h with LPS, Zymosan or CpG in prese...
<p>The localization of mDCs and pDCs in the C57BL/6, NOR and NOD pancreas at the age of 4, 10 and 20...
<p>Islets from db/+, db/db, and MIN6 cells left untreated or treated with the indicated LPS concentr...
<p>(<i>A</i>) Histological analysis of pancreatic tissue sections from mock-treated or LPS-treated C...
<p>(A–C) IL-10, GM-CSF and TNF-α concentrations after stimulation of Mφ in perigonadal adipose tissu...
<p>DCs from B6 mice were co-cultured with P29mtB6 or P29mtSAMP1 cybrids; the supernatant was harvest...
<p>A) <i>Cytokines</i> IL-1β, TNF-α and IL-6 were assayed in the pancreas of mice after 24, 48 or 72...
<p>(A) Real-Time PCR was used to assess IL-12p35, IL-12p40 and IL-10 mRNA on single cell levels befo...
<p>(A) Quantitative real-time PCR was performed on RNA derived from wild-type and WASP15 Tg BMDMs fo...
<p>Cytokine levels of IL6 and TNFα in spleen cell culture supernatant following stimulation with lip...
<p>Serum samples (n>6) were collected from indicated strains of mice untreated (grey bar) or treated...
<p>Different DCs were co-cultured with 1×10<sup>6</sup>/ml lymphocyte in 96-well plates. The superna...
<p><i>A</i>, <i>B</i>, <i>C</i> and <i>D</i>. Following DC maturation, supernatant culture was colle...
<p>Peritoneal macrophages from both young and middle-aged mice were pretreated with medium, 1 µg/ml ...
<p>Unfractionated splenocytes from WT (□) and RasGRP4-null (■) mice were incubated for 24 or 48 h in...
<p>A) The DC were generated from DBA/1J mice and cultured for 18 h with LPS, Zymosan or CpG in prese...
<p>The localization of mDCs and pDCs in the C57BL/6, NOR and NOD pancreas at the age of 4, 10 and 20...
<p>Islets from db/+, db/db, and MIN6 cells left untreated or treated with the indicated LPS concentr...
<p>(<i>A</i>) Histological analysis of pancreatic tissue sections from mock-treated or LPS-treated C...
<p>(A–C) IL-10, GM-CSF and TNF-α concentrations after stimulation of Mφ in perigonadal adipose tissu...
<p>DCs from B6 mice were co-cultured with P29mtB6 or P29mtSAMP1 cybrids; the supernatant was harvest...
<p>A) <i>Cytokines</i> IL-1β, TNF-α and IL-6 were assayed in the pancreas of mice after 24, 48 or 72...
<p>(A) Real-Time PCR was used to assess IL-12p35, IL-12p40 and IL-10 mRNA on single cell levels befo...
<p>(A) Quantitative real-time PCR was performed on RNA derived from wild-type and WASP15 Tg BMDMs fo...
<p>Cytokine levels of IL6 and TNFα in spleen cell culture supernatant following stimulation with lip...
<p>Serum samples (n>6) were collected from indicated strains of mice untreated (grey bar) or treated...
<p>Different DCs were co-cultured with 1×10<sup>6</sup>/ml lymphocyte in 96-well plates. The superna...
<p><i>A</i>, <i>B</i>, <i>C</i> and <i>D</i>. Following DC maturation, supernatant culture was colle...
<p>Peritoneal macrophages from both young and middle-aged mice were pretreated with medium, 1 µg/ml ...
<p>Unfractionated splenocytes from WT (□) and RasGRP4-null (■) mice were incubated for 24 or 48 h in...
<p>A) The DC were generated from DBA/1J mice and cultured for 18 h with LPS, Zymosan or CpG in prese...
<p>The localization of mDCs and pDCs in the C57BL/6, NOR and NOD pancreas at the age of 4, 10 and 20...