More CD3⁺CD4⁺-cells in <i>ex vivo</i> cultures of RE biopsies, compared to normal looking squamous esophageal tissue biopsies.

<p>Panel A depicts percentage of CD4⁺-cells of the population of CD3⁺-cells (CD3⁺CD4⁺) in 14 days <i>ex vivo</i> culture of normal looking squamous epithelial biopsies from controls (C SQ 5 cm: 5 cm above the Z-line), RE patients and (RE 5 cm: 5 cm above the inflamed RE tissue) and BE patients (BE SQ 5 cm: 5 cm above the BE tissue. Panel B represents CD3⁺CD4⁺-percentage in 14 days <i>ex vivo</i> culture of normal looking squamous epithelial biopsies of controls (C SQ 2 cm: 2 cm above the Z-line) and inflamed esophageal tissue of RE-patients (RE). In panel A Kruskal-Wallis test was used. In panel B, a Mann-Whitney test was used. Between panels A and B a paired t-test was used to compare CD3⁺CD4⁺-percentage in <i>ex vivo</i> cultures from RE tissue to normal looking squamous esophageal epithelium taken 5 cm above the gastroesophageal junction from the same RE patients (*p<0.05, **p<0.005). Mean value and SEM are calculated.