The DMN shows chronic pain type specific changes in phase properties.

<p>(<b>A</b>) Brain maps show the group voxelwise average phase differences (Δphase) between the DMN time course and all other brain voxels. Blue-green areas represent smaller phase differences while yellow-red represents greater phase differences. In general CBP and OA patients exhibited decreased phase differences, compared to healthy subjects and CRPS patients. (<b>B</b>) Brain map illustrates clusters of significantly different phase relationship to the DMN, using a whole-brain voxelwise ANOVA (mixed effects analysis, f-zscore >3.0, corrected for multiple comparisons by cluster threshold p<0.01). The DMN in patients show changes in phase relationships to regions within the frontoparietal network inculding bilateral IPS, and FEF in addition to the right DLPFC, and to regions within the salience network including ACC and bilateral anterior and posterior insula. (<b>C</b>) Compass plots show the individual absolute phase differences (Δphase) between the DMN and the network identified in <b>B</b> for all groups. Watson-Williams test for circular data reveals a significant difference of mean phase across groups (F_3,78 = 7.45, p<0.01). Blue lines represent the circular mean. (<b>D</b>) Correlation between Δphase and DMN HF Power. Only CBP and OA patients show a significant relationship.