Gene expression changes associated with <i>H. hepaticus</i> infection and the absence of FXR.

<p>Fold changes of A-G) pro-inflammatory (<i>β-catenin</i>, <i>IL-1b</i>, <i>Nos2</i>, <i>Rela</i>, <i>Tlr2</i>, <i>TNFα</i>, and <i>Trp53</i>) and H-K) metabolic (<i>Cyp3a11</i>, <i>Slc10a1</i>, <i>Vdr</i>, and <i>Cyp2b10</i>) genes determined by qPCR are shown for each group relative to WT sham mice. L) <i>Cyp2b10</i> expression in infected FXR KO mice is shown based on FCA presence vs. absence (<i>P</i> = 0.0028). Box plots represent the average fold change relative to WT sham ±1 standard deviation. Values represent average fold change relative to uninfected WT sham. *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 vs. sham-treated WT mice. ^#<i>P</i><0.05, ^##<i>P</i><0.01, ^###<i>P</i><0.001 vs. <i>H. hepaticus</i> infected WT mice.