<p>(A) PCA (R<sup>2</sup>X = 0.642, Q<sup>2</sup> = 0.178) and (B) PLS-DA (R<sup>2</sup>Y = 0.915, Q<sup>2</sup> = 0.700) models of serum metabolite concentrations of sham C57BL/6 female mice compared with ovariectomized mice with and without Fosamax treatment for 23 weeks. Permutation testing revealed that the model was valid, with all values of the permuted R<sup>2</sup>Y and Q<sup>2</sup> data being significantly less than the original model (p<0.001).</p
*<p>Adult mice at 6 weeks old. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone...
<p>A) OPLS-DA score plot (predictive score vectors t <a href="http://www.plosone.org/article/info:do...
Manually curated list of compounds obtained by targeted peak extraction from differentially expresse...
a<p>Significantly different metabolites between OVX and Fosamax-treated mice or Sham and OVX mice. E...
<p>All the metabolites that have p<0.05 in <i>t</i>-test and VIP score >1 from OPLS-DA are shown for...
<p>(A) Number of metabolites that were significantly (<i>p</i> < 0.05) or not significantly differen...
<p><b>A, C and E.</b> PLS-DA score plots showing distinct metabolomic profiles of PS1 (<b>A</b>), AP...
<p>Score plots (A, C) and corresponding loading plots (B, D) for PCA of UPLC/QTOF MS data from mice ...
<p>Quantitative data of simulated and experimental metabolite concentrations of all three mouse stra...
<p>(A) Welch one-way ANOVA with Turkey Posthoc testing shows 541 statistically different metabolites...
<p>(A) Hydroxyproline (OH-Pro); (B) Phosphatidylcholine PC aa C30:2; (C) Carnosine; (D) Acetylcarnit...
<p>Top panels represent the chromatograms for unlabeled BPA and lower panels labeled BPA ([<sup>13</...
<p>Results are presented as mean ± S.D. (n = 8). * <i>p</i>< 0.05; ** <i>p</i><0.01.</p
<p>This analysis employed three parameters, VIP score from OPLS-DA, p value in <i>t</i>-test, and re...
<p><b>(A)</b> Volcano plot (fold-change vs significance) of the comparison between metabolites of th...
*<p>Adult mice at 6 weeks old. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone...
<p>A) OPLS-DA score plot (predictive score vectors t <a href="http://www.plosone.org/article/info:do...
Manually curated list of compounds obtained by targeted peak extraction from differentially expresse...
a<p>Significantly different metabolites between OVX and Fosamax-treated mice or Sham and OVX mice. E...
<p>All the metabolites that have p<0.05 in <i>t</i>-test and VIP score >1 from OPLS-DA are shown for...
<p>(A) Number of metabolites that were significantly (<i>p</i> < 0.05) or not significantly differen...
<p><b>A, C and E.</b> PLS-DA score plots showing distinct metabolomic profiles of PS1 (<b>A</b>), AP...
<p>Score plots (A, C) and corresponding loading plots (B, D) for PCA of UPLC/QTOF MS data from mice ...
<p>Quantitative data of simulated and experimental metabolite concentrations of all three mouse stra...
<p>(A) Welch one-way ANOVA with Turkey Posthoc testing shows 541 statistically different metabolites...
<p>(A) Hydroxyproline (OH-Pro); (B) Phosphatidylcholine PC aa C30:2; (C) Carnosine; (D) Acetylcarnit...
<p>Top panels represent the chromatograms for unlabeled BPA and lower panels labeled BPA ([<sup>13</...
<p>Results are presented as mean ± S.D. (n = 8). * <i>p</i>< 0.05; ** <i>p</i><0.01.</p
<p>This analysis employed three parameters, VIP score from OPLS-DA, p value in <i>t</i>-test, and re...
<p><b>(A)</b> Volcano plot (fold-change vs significance) of the comparison between metabolites of th...
*<p>Adult mice at 6 weeks old. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone...
<p>A) OPLS-DA score plot (predictive score vectors t <a href="http://www.plosone.org/article/info:do...
Manually curated list of compounds obtained by targeted peak extraction from differentially expresse...