Changes in DA- and DAT-immunoreactivity on reactive astrocytes in the striatum of hemi-parkinsonian rats after L-DOPA administration.

<p>The 6-OHDA-lesioned hemi-parkinsonian rats were treated with L-DOPA/carbidopa treatment (50/5 mg/kg/day, i.p.) for 7 days. The densities of GFAP-positive reactive astrocytes (A), DA- and GFAP-double positive astrocytes (B) and DAT- and GFAP-double positive astrocytes (C) on both the control and lesioned sides of the striatum were evaluated by double immunostaining of DA/DAT and GFAP at 3 h after the final administration. Values are mean ± SEM of 6–8 mice. *p<0.05, ***p<0.001 vs. side-matched vehicle-treated sham-operated, +++p<0.001 vs. side-matched vehicle-treated parkinsonian group, #p<0.05, ##p<0.01, ###p<0.001 vs. intact control side of each treated group.