CCRt of long and short period alleles of clock genes.

<p>The response of mutant females maintained in long (left column) and short (right column) days (thermoperiods) is depicted. Response of <i>per^L</i> and <i>per^S</i> is shown in (A) (44, ÷2 = 11.9, p<0.001; N₁, N₂ = 53) and (B) (χ² = 11.1, df = 1, p<0.001; N₁, N₂ = 53,44). The response of <i>dbt^L</i>, <i>dbt^S</i> is depicted in (C) (χ² = 9.5,df = 1, p<0.05, N₁, N₂ = 29, 20) and (D) (χ² = 2.8, df = 1, p = 0.093; N₁, N₂ = 29,20). The response of <i>tim^S1</i> and <i>tim^UL</i> is shown in (E) (χ² = 18.4, df = 1, p<0.001, N₁, N₂ = 27, 51) and (F) χ² = 1.7, df = 1, P = 0.19; N₁, N₂ = 38, 23). G. Schematic diagram showing Bünnings' external coincidence detector in wild-type (WT) and mutant flies. In WT short days coincide with the photophil phase while long day extend to the schotophil phase (note that daylength may be either encoded by photoperiod or the thermoperiod). In long-period mutants, long days still coincide with the photophil phase, and are interpreted as short days, leading to a constitutively short day response. In short period mutants the photophil phase may be brief so even short day are interpreted as a long one. In both type of mutants, long and short daylength may coincide with the same phase of the detector, resulting in loss of the photo/thermo-periodic response.