<p>Mutated residues are shown in red. (a) Histidine 614 interacts with both the DNA backbone and serine 611. (b) Similarly, arginine 652 also interacts with the DNA backbone and a neighboring amino acid, aspartic acid 608. (c) Lysine 653 is within an appropriate distance to make non-specific contacts with the minor groove of a GRE. (d) Glycine 621 is mutated to aspartic acid in a stomach cancer sample. In the estrogen receptor, the homologous amino acid is the similar glutamic acid, which participates in base-specific DNA recognition (panel e). (f) Cysteine 606 is one of four cysteine residues to coordinate a Zn<sup>2+</sup> ion in one of MR’s two zinc fingers. (g) Phenylalanine 626 comprises part of the hydrophobic core of the DBD. (h) Asp...
The spectrum of somatic cancer-associated missense mutations in the human TP53 gene was studied in o...
<p><b>Copyright information:</b></p><p>Taken from "Novel DNA-binding element within the C-terminal e...
Poster Session 7.1: Biological SystemsThe Book of Abstract can be viewed at: http://www.cerm.unifi.i...
textabstractIn the androgen receptor of a patient with androgen insensitivity, the alanine...
Cancer can be viewed as a set of different diseases with distinctions based on tissue origin, driver...
Cancer can be viewed as a set of different diseases with distinctions based on tissue origin, driver...
<p><b>Copyright information:</b></p><p>Taken from "Novel DNA-binding element within the C-terminal e...
Post-translational modifications (PTMs), such as methylation, are epigenetic mechanisms that regulat...
<p>Alignment shows the amino acid composition of proteins encoded by genomic DNA. Conserved amino ac...
DNA mismatch repair (MMR) is a highly conserved cellular process that functions in the maintenance o...
<p>A, B: Glutamic acid 225 was mutated into Histidine. C, D: Aspartic acid 37 was mutated into Valin...
O6-methylguanine-DNA methyltransferase (MGMT) is one of the major DNA repair protein that counteract...
Understanding the molecular mechanisms that correlate pathologies with missense mutations is of crit...
The androgen receptor (AR) is an important drug target in prostate cancer and a driver of castration...
Inherited missense mutations in the tumor suppressor gene, BRCA-1, may predispose to breast or ovari...
The spectrum of somatic cancer-associated missense mutations in the human TP53 gene was studied in o...
<p><b>Copyright information:</b></p><p>Taken from "Novel DNA-binding element within the C-terminal e...
Poster Session 7.1: Biological SystemsThe Book of Abstract can be viewed at: http://www.cerm.unifi.i...
textabstractIn the androgen receptor of a patient with androgen insensitivity, the alanine...
Cancer can be viewed as a set of different diseases with distinctions based on tissue origin, driver...
Cancer can be viewed as a set of different diseases with distinctions based on tissue origin, driver...
<p><b>Copyright information:</b></p><p>Taken from "Novel DNA-binding element within the C-terminal e...
Post-translational modifications (PTMs), such as methylation, are epigenetic mechanisms that regulat...
<p>Alignment shows the amino acid composition of proteins encoded by genomic DNA. Conserved amino ac...
DNA mismatch repair (MMR) is a highly conserved cellular process that functions in the maintenance o...
<p>A, B: Glutamic acid 225 was mutated into Histidine. C, D: Aspartic acid 37 was mutated into Valin...
O6-methylguanine-DNA methyltransferase (MGMT) is one of the major DNA repair protein that counteract...
Understanding the molecular mechanisms that correlate pathologies with missense mutations is of crit...
The androgen receptor (AR) is an important drug target in prostate cancer and a driver of castration...
Inherited missense mutations in the tumor suppressor gene, BRCA-1, may predispose to breast or ovari...
The spectrum of somatic cancer-associated missense mutations in the human TP53 gene was studied in o...
<p><b>Copyright information:</b></p><p>Taken from "Novel DNA-binding element within the C-terminal e...
Poster Session 7.1: Biological SystemsThe Book of Abstract can be viewed at: http://www.cerm.unifi.i...